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These behavioral benefits are underpinned by its marked ability to induce spinogenesis and promote functional synaptogenesis in hippocampal neurons, highlighting its potential as a robust procognitive and antidementia agent [2]

Unlike the substrate-specific enzyme that hydrolyzes ThTP, synthesis of ThTP is currently known to be catalyzed only by the enzymes producing ATP through ADP phosphorylation

It is worth mentioning that G6PD deficiency can downregulate another enzyme that requires NADPH: the thyroid NADPH oxidase necessary for the synthesis of triiodothyronine (T3) [129], whose lower levels could increase cardiovascular risk [130]

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Insulin secretion is triggered by cytoplasmic increments in ATP levels, derived from glucose internalization and subsequent metabolism (Prentki and Matschinsky, 1987)

Hassanin, I