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Early literature therefore portrayed SQOR primarily as a detoxifying enzyme that prevents H 2 S-mediated inhibition of complex IV, as illustrated by the severe metabolic crises seen in SQOR deficiency (Kanemaru et al., 2024

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Spangenberg, 2001), family disruption (e.g., death, divorce, abandonment, substance abuse, and domestic violence) (Raphael, 2004), school-related problems (Martinez, 2006), and chronic runaways and periods of homelessness (Norton-Hawk, 2002