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Key gene families: collagen synthesis, matrix metalloproteinases, antioxidant defense, angiogenic factors

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First discovered in 1905, L-Carnitine serves as an essential cofactor in cellular energy metabolism, with approximately 95% of the body's carnitine stores located in skeletal muscle and cardiac tissue

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Metabolism (2017) 68:13344.10.1016/j.metabol.2016.12.009 154 CaniPDAmarJIglesiasMAPoggiMKnaufCBastelicaDet alMetabolic endotoxemia initiates obesity and insulin resistance

Notably, treatment with either 1,25(OH) 2 D 3 or the ferroptosis inhibitor ferrostatin-1 reduced the expression of senescence markers in D-galinduced osteoblasts, suggesting that VDR activation suppresses osteoblastic senescence by inhibiting ferroptosis (38)