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The 3-On-4-Off Schedule and Liver Safety The widely referenced three consecutive days on, four days off schedule provides hepatic recovery time between exposure cycles allowing glutathione replenishment and metabolite clearance

Many intracellular biochemical reactions, especially enzymes that use GSH as their substrate, rely on the local GSH concentration instead of E GSH (ref

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The participant, investigator and sponsor were blinded to bimagrumab dose or placebobimagrumab until database lock to avoid bias in reporting adverse events and efficacy