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P53-mediated lipoxygenase and iPLA2 pathway As a tumor suppressor, p53 can inhibit tumor cells by arresting the cell cycle, promoting apoptosis and senescence [30, 31]

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10.1038/ctg.2016.54 108

induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs) can be sequentially differentiated into definite endoderm (DE), posterior foregut (PFG), hepatic progenitor cells (HPCs), and HLCs under small molecule induction