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Intriguingly, recent studies have expanded the therapeutic scope of GLP-1RAs to neuroinflammatory regulation, with promising therapeutic potential observed in neurodegenerative disorders including Alzheimers disease, Parkinsons disease, and amyotrophic lateral sclerosis [271, 272]
Predicted physicochemical properties supported its hydrophobic character and oral bioavailability, suggesting it is a metabolically stable and BBB-permeable molecule [1]
Microglial complement receptor 3 can induce ferroptosis via NADPH oxidase 2 (NOX2) (60), and other NADPH oxidases, including NOX1 (61) and NOX4 (62), are also key contributors to the ferroptotic process