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Chan School of Public Health analyzed pregnancies in women who were taking GLP-1 drugs prior to conception and found that the risk for non-live birth was 29.7% with medication continuation versus 27.1% with non-continuation

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Genetic variants in GLP1R (rs6923761), GIPR (rs1800437), and metabolic pathways like FTO (rs9939609) influence baseline appetite regulation and medication responsiveness

One of the most common reasons is metabolic adaptation

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