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Research published in major endocrinology journals confirms that this appetite-suppression effect is sustained across 1224 months of continuous treatment in women with baseline weights across a broad spectrum

It can be taken with or without food and at any time of the day

It is not recommended in patients with liver cirrhosis by fear of inducing lactic acidosis.42 However, this complication was reported only in anecdotal cases, particularly with concomitant alcohol intake.43 The use of this drug for the treatment of simple steatosis and NASH with or without DM has yielded conflicting results

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Nature 395:913917

These methods are ideal for those who prefer to avoid surgery and medications