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The free tripeptide was first identified in human plasma in 1973 by Loren Pickart as a factor supporting cell proliferation in liver cell cultures, and the copper-binding role of the peptide was recognized shortly afterward as the molecular basis for many of the activities attributed to GHK

Common examples include forearm cramps in keyboard workers, neck and shoulder spasms in desk workers, and hamstring cramps in runners who under-stretch

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Their compatibility with established pharmaceutical supply chains without the constraints of cold-chain logistics, injection training or medical-waste handling creates opportunities to broaden distribution through retail pharmacies and remote care pathways