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Larger, longer exposure is required to characterize rare adverse events and to clarify the significance of the transient heart-rate increase

Higher doses tend to provide the greatest weight loss and metabolic improvements, but are also associated with an increased likelihood and intensity of gastrointestinal symptoms

At the highest dose (17.2 mg), women in postmenopause lost an average of 28.2 pounds (14.1% of their body weight) over 72 weeks, compared with 30.4 pounds (14.4%) among women in perimenopause

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