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Their amphiphilic structure comprising hydrophilic heads and hydrophobic tails allows them to encapsulate both water-soluble and lipid-soluble drugs, making them versatile nanocarriers

Ferroptosis is induced by disruption of glutathione synthesis or inhibition of glutathione peroxidase 4, exacerbated by iron, and prevented by radical scavengers such as ferrostatin-1, liproxstatin-1, and endogenous vitamin E

In another two studies, tighter monolayers, as assessed by mannitol permeability, explained the decreased drug permeability

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Prior work has shown that metabolic syndrome and its components are associated with worse osteoarthritis symptomatology, including pain and impaired knee function ( Current guidelines already place physical activity and weight management at the core of non-surgical KOA care, yet implementation remains difficult in real-world practice