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While some researchers have attempted to decipher the pathophysiological mechanism behind IBS-C and FC and its associated abdominal pain, no summative evidence has been synthesized, pointing to the urgency of comprehensive reviews of studies addressing these particular issues

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PT-141 was developed to interact primarily with the Melanocortin-4 Receptor (MC-4R), although other melanocortin receptors (MC-1R, MC-2R, MC-3R, and MC-5R) may also play varying roles in physiology

10.1038/nm919 53 DuttaD.SuranaV.SinglaR.AggarwalS.SharmaM

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