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Selenium toxicity (selenosis) can occur with chronic excessive intake and may cause: Gastrointestinal disturbances (nausea, diarrhoea) Hair loss and brittle nails Skin rashes and lesions Neurological symptoms (peripheral neuropathy, fatigue, irritability) Garlic-like breath odour In severe cases, liver and kidney damage Safe consumption guidelines: Limit intake to one to two Brazil nuts per day to obtain selenium benefits whilst avoiding toxicity risk Avoid consuming Brazil nuts daily if taking selenium supplements Be aware that selenium content varies significantly between nuts Consider overall dietary selenium intake from other sources (fish, meat, eggs, cereals) Seek medical advice if you experience symptoms that might suggest selenosis Additional considerations: Brazil nuts are calorie-dense and may contribute to weight gain if consumed in large quantities

Lifespan changes have been reported in flies and selected mouse models

Retatrutide Phase 3 Trials and Future Price Trajectory Eli Lilly initiated two phase 3 trials in 2023: TRIUMPH-1: Retatrutide versus placebo in adults with obesity, primary completion estimated Q2 2026

Instead, it modulates sleep architecture promoting deeper delta wave sleep and regulating the neuroendocrine systems that control sleep quality

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Further reading & external resources Independent, third-party references on public scientific databases and registries