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The administration of cysteine-rich glutathione precursors, especially N-acetyl cysteine, has been shown to increase intracellular glutathione levels

This means that there is less ability in the cells of people with Down syndrome to perform the chemical reaction (methylation)

Given the hair cycle timeline (anagen phase lasts 2-6 years, with visible changes requiring multiple months), published community timelines describe 3-6 months as the minimum assessment period