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Pinto, M, Neves, J, Palha, M, and Bicho, M

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Vitamin B(12) deficiency and depression in physically disabled older women: epidemiologic evidence from the Women's Health and Aging Study

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The specific thresholds that should prompt dose reduction or discontinuation include: ALT or AST elevation exceeding 3 times the patient's baseline value, new or worsening coagulopathy (INR increase of 0.5 or more from baseline), albumin decline below 2.5 g/dL, or new clinical signs of hepatic decompensation such as worsening ascites, encephalopathy, or jaundice [5]

Loss of NCOA4 substantially decreases ferroptosis susceptibility, reducing cell death by approximately 62% (Savo and Dill, 2019)