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Acknowledgements We would like to acknowledge the following funding sources: R01 CA196660, P50 CA121974, P01CA128814, the Melanoma Research Alliance, the Melanoma Research Foundation and the Hervey Family Foundation (to MB)

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Practical considerations that affect your decision Beyond the science, real-world factors influence which delivery method works best for your life

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Carnitine deficiency is defined biochemically as abnormally low plasma concentrations of free carnitine, less than 20 mol/L at one week post term and may be associated with low tissue and/or urine concentrations

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The animal experiments were based on ethical considerations and integrity-based assumptions, and the experimental protocols were approved by the Institutional Animal Ethics Committee of the First Hospital Affiliated to Hebei North College, following the guidelines of the Committee for the Control and Supervision of Animal Experiments

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On a U-100 syringe, 100 units = 1 mL, so 1 unit = 0.01 mL

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We used Egger at al.s (1997) method to assess for publication biases

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