Clinical data from Eli Lilly and Novo Nordisk confirms equivalent pharmacokinetic exposure across abdomen, thigh, and upper arm
The results of previous trials are encouraging in terms of multiple positive effects of GLP-1 receptor agonists
On most insulin syringes, this is roughly 0.5 to 1 unit
A 10mg vial reconstituted with 2mL of bacteriostatic water gives you 5,000mcg per mL
Paid subscribers have also received our view on being long smaller, clinical stage names like Gubra (GUBRA DC), Zealand Pharma (ZEAL DC) and Amgen (AMGN US)
On the basis of the overall evidence, it seems that sequential or concomitant use of SGLT2is and GLP-1 RA provides the most favorable approach based on their CV protection (heart failure and major adverse cardiovascular events), glycemic control (HbA1c lowering), and metabolic effects (attenuation of compensatory hyperphagia, weight loss, and minimal risk of hypoglycemia)