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It also participates in the action of serotonin, a neurotransmitter known to control mood and appetite

In phase 3 trials, after 56 weeks of treatment, 62% of patients receiving contrave 32 (bupropion SR 360 mg/naltrexone SR 32 mg) lost at least 5% of their body weight as compared to 23% of patients in the placebo group [240]

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doi: 10.2165/00003495-199856060-00019

5-Amino-1MQ (10mg Vial) Dosage Protocol Experimental NNMT-inhibitor small molecule studied for fat metabolism preclinical only, not approved