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Furthermore, the presence of a carbonyl (= O) group is essential for BDNF activity

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Hao S, Pan S, Hu J, Qian G, Gan F, Huang K (2015) Aflatoxin B1 suppressed T-Cell response to anti-pig-CD3 monoclonal antibody stimulation in primary porcine splenocytes: a role for the extracellular regulated protein kinase (ERK1/2) MAPK signaling pathway

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Conversely, those starting at the lowest available dose typically progress through side effects more rapidly

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