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The net result varies by individual

Contributes to reducing the risk of complications of type 2 diabetes, such as diabetic neuropathy and retinopathy

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The leading example is its co-development with cagrilintide (formerly AM833), a long-acting analogue of amylin, the hormone co-secreted with insulin that slows gastric emptying, suppresses glucagon after meals and enhances meal-related satiety

Leptin is a hormone involved in regulating energy balance and appetite, which could imply that increased food intake may contribute to the observed weight gain in peptide-exposed models, which then may increase leptin levels and subdue appetite

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