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studied the hypoglycemic effect of aqueous extracts of garlic as well as several different organic solvent extracts on normal and alloxaninduced diabetic rabbits (Jain et al., 1973)

Different hypotheses are considered, including a compensatory relationship between incretin receptors by which GIPR enhances GLP-1R activity and/or that chronic GIPR agonism produces desensitisation and loss of GIPR activity, thus, mimicking antagonism

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Choosing the right method depends on factors such as absorption rate, lifestyle, treatment purpose, and the desired speed of results