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In 2009, Richard DiMarchi and Matthias H Tschp's team reported that dual agonists targeting GLP-1R/GCGR did better in weight loss compared to GLP-1RA [10]

doi: 10.1016/j.dsx.2022.102539 29

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Decreased BDNF in the hippocampus and PFC has been noted in depressed patients (Krishnan and Nestler, 2008

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