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This stepwise escalation principle mirrors the approach used for licensed medicines such as semaglutide (Wegovy, UK SmPC available via the electronic Medicines Compendium) and tirzepatide (Mounjaro, UK SmPC available via the electronic Medicines Compendium), both of which are approved by the MHRA and recommended within relevant NICE guidance for specific indications

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Telogen effluvium from rapid weight loss (up to 24%) is the likely cause

Typically decreases in severity after 2-4 weeks of treatment Constipation When it happens: Often develops gradually after starting treatment How to manage it: Gradually increase fiber intake

They provide a much stronger and longer-lasting signal than your bodys natural GLP-1 can produce on its own

Janssen, et al (2012)