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The three structural modifications (an Aib substitution at position 8, a C-18 fatty di-acid chain attached via a linker at lysine-26, and an amino acid substitution at position 34) collectively reduce dipeptidyl peptidase-4 (DPP-4) cleavage and promote strong, non-covalent albumin binding 1

Thus, several differential proteins were identified according to this cotreatment, i.e

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pharmaceutical market for GLP-1 receptor agonists (RAs) indicated for Type 2 diabetes and chronic weight management