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Furthermore, the increase in lipid peroxidation in the renal tissue causes the overconsumption and depletion of functional thiol (-SH) groups in several enzymatic and non-enzymatic molecules 30

The Michaelis constants ( K m ) were 1.53 0.12 mM for GSH and 1.35 0.10 mM for CDNB (Table 1)

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By effectively competing with NF-B for these coactivators, NRF2 limits their availability, resulting in reduced NF-B transcriptional activity and dampening the NF-B-dependent expression of pro-inflammatory genes [117,118,119]

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