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PVL is due to three main mechanisms: hypoxia/ischemia of the vascular border zone, inflammation, excitotoxicity and free radical attack

Murphy AA, Santanam N, Parthasarathy S: Endometriosis: a disease of oxidative stress

However, when administering a lower dose of 2APB, i.e., 1 mg/kg, the protective effect on APAP tolerance was observed only in wild-type mice, for which survival rate was 100% at 60 h post-2APB administration

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