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Immunology: Assesses thymic activity, lymphocyte function, and cytokine signaling in aging models

Skipping doses or extending intervals beyond seven to ten days can reduce the medication's effectiveness, as the hormone concentration drops below therapeutic levels

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We summarize mechanistic insights across cellular and molecular domains, critically appraise preclinical and clinical findings, and discuss translational challenges that include bioavailability and brain penetration, study heterogeneity, biomarker guided stratification, and pediatric safety