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Platinum agents may have an immunosuppressive effect on the TME by promoting M2 TAM polarization (118)

It is NOT a long-term solution, but it can protect the body from the full extent of damage

McGuinness AJ, Sapey E

In addition, since some studies have also recorded failure in antioxidant supplementation efficacy, optimal design of clinical trials in terms of targeted delivery of antioxidants, clinical pathology and concentration dependent dosage schedule is needed to go ahead in the knowledge and future application of this kind of treatment in CIPN (Kamat et al., 2008)

Diaz-Villanueva, J