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Tier 2: Partial Documentation Acceptable with Caution Criteria partially met: HPLC purity shown but no MS confirmation, in-house lab only, or COA not batch-specific

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Many vaccines and neonatal medications fall into this category, where even small amounts of preservatives are not acceptable

Another possibility is that obesity could lower serum vitamin B12 levels through decreased dietary intake or absorption, increased catabolism, and sequestration in adipose tissue, or changes in the gut microbiota profiles which could affect the metabolism of vitamin B12

Patients with neurological features should begin to show clinical improvement six months after initiation of anti-copper therapy[18]