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tubulin or cochlin), leading to progressive SNHL and tinnitus

[DOI] [PubMed] [Google Scholar] 25.Gitelman SE, Bristow J, Miller WL

For example, in colon cancer cells (PC-3 cell line), at curcumin concentrations ranging from 0 to 50 M, treatment was associated with decreased phosphorylation of Akt kinase (Akt), mammalian target of rapamycin (mTOR), glycogen synthase kinase (GSK3), Forkhead box protein O1 (FOXO1), and other proteins (Yu et al., 2008)

Notably, RN is a late effect of SRS, such that treatment has already been delivered at the time it presents with radiographic changes

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