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Mitophagy defects have been found in neurodegenerative diseases such as Hungtingtons disease, Alzheimers disease and Parkinsons disease (Schapira and Gegg, 2011

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In the trials, the most common were: Nausea Diarrhea Constipation Vomiting These effects were usually mild to moderate and tended to show up early in the first few weeks of treatment or right after a dose increase

Studies have linked hyperthyroidism to low levels of CoQ10, so I recommend it for all of my hyperthyroid patients

However, this plateau phenomenon reflects normal physiological adaptations rather than true drug tolerance

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