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Tumor-associated macrophages (TAMs), cancer-associated fibroblasts (CAFs) and myeloid progenitor cells also tend to cluster at the invasive edge of the primary tumor, where they play an immunosuppressive role by interfering with dendritic cell differentiation

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& Cataletto, M

PMID: 38675421

In the era of multiple biomarker development, panels of biomarkers, including GST, should be validated for additional value in combining more than one biomarker

Thus, it should be clear that any disruption in the level of NADPH may have a profound effect upon a cells ability to deal with oxidative stress