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The prevalence of kidney diseases is over 10% worldwide (Huang et al., 2021)

There is evidence in other cancer types that point towards using wildtype IDH1 inhibition in combination with chemotherapy as a strategy for treatment, although these studies focused on redox balance and ROS (Vaziri-Gohar et al., 2022

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That said, its important to note that responses can vary depending on species, dosage, and experimental conditions

If a 3% reduction in baseline body weight is not observed after 12 weeks, the dosage can be escalated to 11.25/69 mg for an additional 14 days and subsequently increased to 15/92 mg daily

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