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GHK-Cu promotes fibroblast proliferation, collagen synthesis, angiogenesis, and ECM remodeling, while KPV, including advanced formulations such as KPV@PPP_E, exerts anti-inflammatory effects and supports tissue repair

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A clinical study in Thailand evaluated this combination in 50 patients with mild to moderate acne after an initial intensive treatment phase (0.1% adapalene and benzoyl peroxide 2.5% for eight weeks)