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doi: 10.1186/s13041-021-00803-9 50 OldendorfW

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Relative Contraindications (Use with Caution): Severe renal impairment (eGFR below 30), diabetic retinopathy, severe gastroparesis, history of gallbladder disease, concurrent use of insulin or sulfonylureas (hypoglycaemia risk)

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Most notably, the way they help you lose weight is completely different, with Wegovy being a GLP-1 agonist that reduces hunger, manages blood sugar, and slows gastric emptying while phentermine only targets hunger

Special populations and interactions Older adults sometimes have lower carnitine production and may respond differently to supplementation