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With promising preclinical data showing significant weight loss effects, GUBamy holds tremendous potential as a novel treatment option for obesity, both as a monotherapy and in combination with other anti-obesity drugs

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We demonstrate that two peptide biased agonists (GEP44 and GEP12) of the GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors (GLP-1R, Y1-R, and Y2-R, respectively) elicit Y1-R antagonist-controlled, GLP-1R-dependent stimulation of insulin secretion in both rat and human pancreatic islets, thus revealing the counteracting effects of Y1-R and GLP-1R agonism

It included 26 patients who were randomly assigned a KD or MD for 8 weeks