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Damage to axons is mediated by the following: (1) failure in mitochondrial energy metabolism due to inhibition of the respiratory chain by nitric oxide, which in turn causes a decrease in Na + /K + ATPase activity and alters Na + dependent glutamate transporters, (2) overexpression of glutamate receptors, (3) oligodendroglial excitotoxicity, (4) massive influx of extracellular Ca ++ , (5) activation of proteases, and (6) impaired axonal transport
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Matt Lesser, a Middletown Democrat and co-chair of the Human Services Committee, who sponsored the prescription drug legislation with members of the Bipartisan Drug Task Force, said there are a number of legal and practical questions that the state must address to make a compelling case to the federal government to manufacture the drug
A third paper from 2013 remains under a 2021 expression of concern
Bile acid: a potential inducer of colon cancer stem cells