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In pulmonary fibrosis studies using bleomycin-induced injury in mice, doses of 2.6-260 g/mL/day administered every other day from day 4-21 reduced inflammatory cell infiltration, decreased interstitial thickness, and reduced TNF- and IL-6 expression

Given the early stages of this therapeutic approach senescence therapeutics will need to overcome challenges related to biomarker identification, target engagement, CNS penetrance and safety

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