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All patients who have taken a double dose should contact NHS 111 or their GP surgery for advice, even if they feel well initially, as symptoms may develop or worsen over the subsequent hours

For upper arms, use the back portion in small vertical strips

Key takeaways from TRIUMPH-4 (68 weeks): 28.7% average weight loss at the highest dose 1 in 4 participants lost 35% of body weight ~76% reduction in knee pain Meaningful improvements in BP and lipid markers This pushes weight-loss outcomes closer to bariatric-surgery territory, while also improving joint pain and cardiometabolic risk

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if you develop signs of severe dehydration, pause your medication and seek medical attention

Indeed, both TNF- and IL-1 can stimulate ROS production and inhibit mitochondrial respiration, whilst increasing glycolytic activity and lactate production (199)