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Jun 5 2014;510(7503):92-101

It serves as a primary defender against oxidative stressa state where unstable molecules called free radicals outnumber the body's antioxidants

Several mechanisms have been reported for the increased activity of NRF2 in cancers ( Figure 5 ): (1) somatic mutations in KEAP1 or NRF2 , (2) DNA hypermethylation at the promoter region of KEAP1 , (3) the aberrant accumulation of proteins that disrupt the KEAP1NRF2 interaction, (4) transcriptional up-regulation of NRF2 gene through oncogene-dependent signaling, and (5) the modification of KEAP1 protein through oncometabolites

Use - maintains proper energy levels

In young lenses, the ratio of primary to secondary is approximately 10:1, but this decreases with age to 2:1 (91)

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