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For example, astrocytes express different antioxidant molecules such as glutathione peroxidase (EC 1.11.1.9), which have been inversely correlated with the severity of dopaminergic cell loss in the respective cell groups in patients with PD [4]

This mechanism is critical because neurons have a limited ability to synthesize endogenous GS ( Oxidative stress in the CNS acts as a persistent inflammatory trigger by activating brain-resident immune cells, particularly microglia and astrocytes

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