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doi:10.1186/s13048-020-00743-3

Inflammopharmacology 28(6):14771480

Electrophysiological recordings further supported this, revealing that Dihexa caused a 1.6-fold increase and Nle-AngIV caused a 1.7-fold increase in the frequency of AMPA-mediated mEPSCs compared to vehicle-treated neurons, indicating an expansion of functional synapses without altering individual synapse properties such as amplitude, rise, or decay times

therefore, current research efforts have focused on novel strategies that can act locally rather than systemically in the skin and/or can selectively activate ER to safely promote wound healing in estrogen-deficient patients (Figure 4)

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