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The TH gene is located on chromosome 11p15.5 and is composed of 14 exons that generate three alternatively spliced mRNAs that encode tyrosine hydroxylase isoform a (528 amino acids), isoform b (497 amino acids), and isoform c (524 amino acids)

Structurally, SIRT1 contains a conserved catalytic core domain (275 amino acids) located in the central region of the protein

Dementia and Geriatric Cognitive Disorders, 42(56)

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