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However, individual responses vary based on baseline metabolic health, existing medication regimens, and genetic factors affecting GLP-1 receptor sensitivity
References IDF Diabetes Atlas: global estimates for the prevalence of diabetes for 2015 and 2040
Known hypersensitivity to semaglutide or to any of the product components [see Warnings and Precautions (5.7)]
Notably, one study included in the meta-analysis, with a follow-up period of at least 2 years, showed that GLP-1 RAs were associated with a lower risk of MAKEs, and protocol biopsies results indicated that GLP-1 RAs may promote tubular cell regeneration in the kidney graft [59]