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However, this mechanism also means a higher burden on the gastrointestinal system, which may explain why severe side effects are becoming more common

While switching metformin to acarbose initially worsened the blood glucose level, the metformin add-on therapy to the Sita+Acarb group effectively lowered the HbA1c level by 0.61%0.12% in 8 weeks

Other causes include: pregnancy, caffeine, alcohol or spicy food

Whilst diarrhea occurs in up to 20% of patients treated with GLP-1RA, 118 national registry studies from Denmark, 89 Israel, 92 and the USA, 93 collectively involving over 10 000 patients with IBD, found no indication that GLP-1RA use was associated with worsening of IBD symptoms or increased adverse event rates

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Psychiatry 7, e1058