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Indirect effects The hypoxia-induced acidic microenvironment of tumors can affect drug efficacy 45 , and promote the phenotypic expression of breast cancer stem cells (CSCs) and the acquisition of MDR in breast cancer

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Irisin treatment can alleviate renal injury, reduce the inflammatory response, increase mitochondrial function, and mitigate oxidative stress after IR injury, and its effects are accompanied by the upregulation of GPX4 expression and inhibition of ferroptosis (Fig

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The 10 nm Au NPs had the most extensive organ distribution including blood, liver, spleen, kidney, testis, thymus, heart, lung, and brain, while the larger NPs were only found in blood, liver, and spleen