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Patients were to be on a stable combined dose of metformin HCl extended-release or immediate-release (at maximum tolerated dose, with minimum dose for enrollment being 1,500 mg) and a sulfonylurea (at maximum tolerated dose, with minimum dose for enrollment being 50% of the maximum recommended dose) for 8 weeks prior to enrollment

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Diabetes, for instance, can reduce semen quality and impair sexual function, while high blood pressure can have similar effects