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Indeed, studies have reported a rebound weight gain upon discontinuation of the drug, in some cases exceeding the patients baseline weight, further strengthening the case for the multidisciplinary approach described earlier in this article

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In addition, a study indicated that DPP-4 inhibitors could improve endothelial function and reduce renal and vascular oxidative stress, which was independent of albuminuria-lowering or improvement in glucose control, in patients with T2DM and chronic kidney disease [54]

Similarly, a high-protein diet exhibits oxidative stress

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