The most performance-relevant outcome is improved oxygen delivery, because B12 deficiency directly causes anemia and reduced VO2 max regardless of training
Common Side Effects (Generally Mild): Temporary injection site reactions (redness, slight swelling) Mild fatigue initially (as metabolism adjusts) Occasional flushing or warmth Slight changes in appetite Contraindications and Precautions: Pregnancy or breastfeeding (insufficient safety data) Active cancer (theoretical concerns about growth pathways) Severe kidney or liver disease (requires monitoring) Hypoglycemia risk (monitor if on diabetes medications) Medical Monitoring: At The Lamkin Clinic, we monitor MOTS-C patients with: Baseline metabolic labs (glucose, HbA1c, insulin, lipids) Follow-up testing at 8-12 weeks Body composition analysis Assessment of symptoms and energy levels Adjustment of other medications as metabolism improves Important: MOTS-C should only be used under the guidance of a qualified healthcare provider experienced in peptide therapy
Werner M, Purta E, Kaminska K.H., Cymerman I.A., Campbell D.A., Mittra B, Zamudio J.R., Sturm N.R., Jaworski J., Bujnicki J.M., "2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family", Nucleic Acid Res 11: 4756-4768 (2011)
Be sure to chill and freeze your low histamine bone broth quickly, and defrost it just before consuming rather than letting it sit
Ethics standards This article does not contain any studies with human or animal subjects
Accessed May 14, 2025
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