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This interacts with the inflammatory pathway triggered by urate crystals, jointly promoting the progression of hyperuricemia to gout, exacerbating joint damage, and contributing to the chronicity of the condition, thereby influencing the course of gout development
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ARDs, which include rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, and axial spondyloarthritis, are characterised with chronic systemic inflammation that accelerates atherogenesis and substantially increases premature cardiovascular death
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